Case Study 2: Advanced Pathophysiology of Acute Myelogenous Leukemia (AML)
A 45-year-old male presents to the hematology clinic with symptoms of progressive fatigue,
frequent bruising, and recurrent nosebleeds over the past few weeks. On physical examination,
he appears pale and has petechiae on his lower extremities. Blood tests reveal a white blood cell
count of 50,000/mm³ with 60% blasts, hemoglobin of 8.5 g/dL, and platelets of 25,000/mm³. A
bone marrow biopsy confirms the diagnosis of AML, showing hypercellularity with 70%
myeloblasts. Cytogenetic analysis reveals a FLT3-ITD mutation, placing him in the intermediate-
risk category.
In 1 -2 pages, answer the questions below in detail. You must use current evidence-based
resources to support your answers. Follow APA guidelines. Follow the grading rubric.
Questions:
1. What is the primary cellular abnormality in AML?
2. How does the accumulation of leukemic blasts affect normal hematopoiesis?
3. What role do genetic mutations play in the development of AML?
4. Why do patients with AML often present with symptoms like fatigue infections and
bleeding?
5. What is the significance of Auer rods in the diagnosis of AML?
6. What is the impact of AML on the immune system?
7. How do treatment strategies target the pathophysiological mechanisms of AML?
Grading Criteria
Develop a 1- to 2-page case study analysis, examining the patient signs and symptoms presented in the case study; discussing the primary cellular pathophysiological processes, and the significance for symptom development and diagnosis.
The response discusses the primary cellular pathophysiological processes, and the significance for symptom development and diagnosis. … The response is supported by evidence and/or research, as appropriate, to support the explanation.
What role do genetic mutations play in the development of the disease?
Excellent
The response includes an accurate, complete, detailed, and specific analysis of the genes that may be associated with the development of the disease.
What is the impact of the disease on the immune system? …… How do treatment strategies target the pathophysiological mechanisms of the disease?
Excellent
The response includes an accurate, complete, detailed, and specific explanation of the impact of the disease on the immune system. Response includes an accurate, complete, detailed, and specific explanation of how treatment strategies target the pathophysiological mechanisms of the disease.
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